Revisiones en Cáncer 00100 / http://dx.doi.org/10.20960/revcancer.00100
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Revisión

Papel de los inhibidores de la PARP en cáncer de ovario


Antonio Casado, Melody Marrero, Marina García, Aitor Cabello, Gloria Marquina

Prepublicado: 2025-01-14

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En esta revisión se discutirán los iPARP estudiados en cáncer de ovario, sobre todo los disponibles en nuestro medio, haciendo hincapié en los principales estudios clínicos y en su valor como terapia de mantenimiento en diferentes contextos de la enfermedad, como la de reciente diagnóstico, así como su uso en la enfermedad recurrente, tanto como terapia de mantenimiento como formando parte de posibles opciones terapéuticas exentas de quimioterapia. Se ha dado una relativa cobertura importante a la enfermedad recurrente como área de innovación y de testado de nuevas estrategias para ofrecer una visión del rico campo de investigación que constituye esta área de la oncología. A lo largo del texto se orienta hacia los nuevos estudios en marcha, las áreas en las cuales deberían desarrollarse esfuerzos en los próximos años, muy especialmente en el ámbito de nuevas estrategias para aumentar la eficacia de estos tratamientos y restaurar o evitar mecanismos de resistencia a ellos, como la restauración de la recombinación homóloga en sus funciones reparativas, la estabilización de la horquilla replicativa, cambios en la función de las enzimas PARP y activación de vías alternativas.

Palabras Clave: Inhibidores de PARP. Cáncer de ovario y tratamiento de mantenimiento. Olaparib. Niraparib. Rucaprib. Cáncer de ovario.



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