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Tratamiento del cáncer de mama metastásico hormonosensible en primera línea

Ignacio Chacón López-Muñiz, Juan David Cárdenas, Irene Otero Blas

Prepublicado: 2023-07-12
Publicado: 2023-07-12
VOLUMEN 37, NÚM. 1, enero-febrero (2023), PAG. 30-37

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Después de mucho tiempo sin novedades terapéuticas, desde hace unos 5 años el tratamiento de los cánceres de mama luminales metastásicos ha cambiado de forma sustancial. En la actualidad el estándar se basa en los inhibidores de las cinasas 4 y 6 dependientes de ciclina, los iCDK4/6: palbociclib, ribociclib, abemaciclib. Su incorporación a la primera línea, siempre combinados con tratamiento endocrino, (AI [letrozol, anastrozol, exemestano] o fulvestrant) ha modificado el pronóstico de estas pacientes, aumentando en todos los casos de forma significativa la supervivencia libre de progresión (PFS). El único que ha conseguido ampliar la supervivencia global (OS) ha sido el ribociclib. Sin embargo, se espera que el abemaciclib también lo haga cuando se produzcan los eventos necesarios. El palbociclib ha obtenido ventaja en la OS en los estudios de vida real, pero no en los ensayos clínicos. La toxicidad de los tres iCDK4/6 es similar, muy controlable y previsible, y se han convertido en el nuevo estándar de primera línea en los tumores luminales metastásicos.

Palabras Clave: Ribociclib. Palbociclib. Abemaciclib. Supervivencia global. Supervivencia libre de progresión. Hormonoterapia.



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Revisión: Carcinoma localmente avanzado. Hormonoterapia neoadyuvante en cáncer de mama con expresión de receptores hormonales y HER2 negativo

Publicado: 2023-03-29 / http://dx.doi.org/
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