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Futuro y líneas de investigación clínica del cáncer de mama triple negativo avanzado

Javier Blanco Ávila, María Olmedo López-Frías, Sandra Rubio Bernabé, Marta Santisteban Eslava

Prepublicado: 2023-07-12
Publicado: 2023-07-12
VOLUMEN 37, NÚM. 1, enero-febrero (2023), PAG. 17-29

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El cáncer de mama triple negativo se caracteriza por una alta tasa de recaídas con respecto al resto de subtipos biológicos y por un peor pronóstico, con una supervivencia que no alcanza los 2 años desde la aparición de las metástasis a distancia. Esto es debido en gran medida a la gran heterogeneidad intratumoral, la ausencia de dianas oncogénicas drogables identificadas y a una mayor agresividad tumoral, que conllevan una alta tasa de resistencias terapéuticas. Con este artículo pretendemos ahondar en la aplicación de nuevas estrategias terapéuticas en estudio (anticuerpos droga conjugados, terapia endocrina antiandrogénica, inhibidores de PARP, inmunoterapia con inhibidores de punto de control inmune y/o con terapia celular) en monoterapia o en diferentes combinaciones para las pacientes con cáncer de mama avanzado triple negativo que puedan impactar en la supervivencia de las pacientes.

Palabras Clave: Cáncer de mama triple negativo. Estadio avanzado. Nuevas terapias.



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