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Revisiones en Cáncer 00033 / http://dx.doi.org/10.20960/revcancer.00033

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Cáncer de mama triple negativo: segunda y sucesivas líneas de tratamiento

Fernando Henao Carrasco, Sara Leal Sánchez

Prepublicado: 2023-07-12

Publicado: 2023-07-12

VOLUMEN 37, NÚM. 1, enero-febrero (2023), PAG. 8-16

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El cáncer de mama metastásico triple negativo constituye en la actualidad un reto en la consulta de oncología de cáncer de mama. Tradicionalmente la quimioterapia en monoterapia de manera secuencial ha sido el tratamiento estándar en segunda y sucesivas líneas. En la actualidad estamos asistiendo a una revolución terapéutica con la aparición de nuevas terapias, como la inmunoterapia o los anticuerpos conjugados, así como combinaciones de ambos, que están consiguiendo incrementos en supervivencia en una enfermedad que, por desgracia, sigue siendo de mal pronóstico desde el momento del diagnóstico. La aparición de nuevos fármacos diana y de nuevas vías de alteración molecular suponen la introducción de nuevos estándares de tratamiento en líneas avanzadas de la enfermedad. En los próximos años muy probablemente asistiremos a una ampliación en las posibilidades de tratamiento y a un cambio en la secuencia óptima de tratamiento gracias a la aparición de estos nuevos fármacos.

Palabras Clave: Cáncer de mama metastásico. Triple negativo. Anticuerpos conjugados. Sacituzumab govitecán. Quimioterapia.

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