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Revisiones en Cáncer H0164

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Revisión

Cirugía de cáncer localmente avanzado de mama

Publicado: 2023-03-29

VOLUMEN 36, NÚM. 6, noviembre-diciembre (2022), PAG. 271-338

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Los cánceres de mama localmente avanzados (CMLA) se definen como tumores de mama voluminosos o que afectan estructuras vecinas o adenopatías extensas en pacientes en las que se ha descartado metástasis de cáncer de mama. La incidencia de CMLA ha disminuido con el tiempo, probablemente debido a los programas de detección de cáncer de mama y al conocimiento de la población general sobre la importancia de la consulta precoz ante cambios en la mama. La quimioterapia es el enfoque convencional para pacientes con CMLA. La terapia endocrina neoadyuvante es una opción en los tumores con receptores hormonales positivos, especialmente en mujeres de edad avanzada. La radioterapia neoadyuvante puede ser una opción terapéutica de rescate para pacientes que no son candidatas a recibir tratamiento sistémico. Antes del tratamiento primario se necesita una estadificación exhaustiva. La estadificación local debe incluir exploración física, mamografía, ecografía axilar y, en casos seleccionados, resonancia magnética nuclear (RMN). Las metástasis a distancia pueden detectarse mediante FDG-PET/TC o TC convencional más gammagrafía ósea si no se dispone de FDG-PET/TC. El marcaje de los tumores de mama y ganglios positivos permite un correcto abordaje quirúrgico postratamiento neoadyuvante (TNA). La RMN es la herramienta más útil para valorar la respuesta del cáncer a la terapia neoadyuvante. En casos de buena respuesta a esta, permite reducir la agresividad quirúrgica. Los pacientes seleccionados que no pueden ser tratados con TNA pueden beneficiarse de resecciones extensas con tejido autólogo o reconstrucciones complejas de la pared torácica. Los ensayos clínicos multicéntricos prospectivos son la mejor opción para los pacientes con LABC. Todos los pacientes con LABC deben ser tratados por equipos multidisciplinarios.

Palabras Clave: Cáncer de mama localmente avanzado. Tratamiento neoadyuvante. Quimioterapia. Cirugía.

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Brito RA, Valero V, Buzdar AU, et al. Long-Term Results of Combined-Modality Therapy for Locally Advanced Breast Cancer With Ipsilateral Supraclavicular Metastases: The University of Texas M.D. Anderson Cancer Center Experience. J Clin Oncol 2001;19(3):628-33.

Sabel MS. Locally advanced and inflammatory breast cancer. In: Sabel MS, editor. Essentials of Breast Surgery. Philadelphia: Mosby; 2009. p. 289-96.

Dawood S, Merajver SD, Viens P, et al. International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. Ann Oncol 2011;22(3):515-23.

Lin YH, Chidley P, Admojo L, et al. Pathological Complete Response and Oncological Outcomes in Locally Advanced Breast Cancers Treated with Neoadjuvant Radiotherapy: An Australian Perspective. International Journal of Radiation Oncology Biology Physics 2022;114(3):e7.

Fisher B, Bryant J, Wolmark N, et al. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol 1998;16(8):2672-85.

Gianni L, Baselga J, Eiermann W, et al. Phase III trial evaluating the addition of paclitaxel to doxorubicin followed by cyclophosphamide, methotrexate, and fluorouracil, as adjuvant or primary systemic therapy: European cooperative trial in operable breast cancer. J Clin Oncol 2009;27(15):2474-81.

Scholl SM, Asselain B, Palangie T, et al. Neoadjuvant chemotherapy in operable breast cancer. Eur J Cancer 1991;27(12):1668-71.

Escrivá-de-Romaní S, Arumí M, Zamora E, et al. Neoadjuvant Model as a Platform for Research in Breast Cancer and Novel Targets under Development in this Field. Breast Care 2018;13(4):251-62.

Von Minckwitz G, Huang C-S, Mano MS, et al. Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer. N Engl J Med 2019;380(7):617-28.

Ilic L, Haidinger G, Simon J, et al. Trends in female breast cancer incidence, mortality, and survival in Austria, with focus on age, stage, and birth cohorts (1983-2017). Sci Rep 2022;12(7048).

Van der Meer DJ, Kramer I, van Maaren MC, et al. Comprehensive trends in incidence, treatment, survival and mortality of first primary invasive breast cancer stratified by age, stage and receptor subtype in the Netherlands between 1989 and 2017. Int J Cancer 2021;148(9):2289-303.

Baeyens-Fernández JA, Molina-Portillo E, Pollán M, et al. Trends in incidence, mortality and survival in women with breast cancer from 1985 to 2012 in Granada, Spain: a population-based study. BMC Cancer 2018;18(1):781.

Mentrasti G, Cantini L, Vici P, et al. Rising incidence of late stage breast cancer after COVID-19 outbreak. Real-world data from the Italian COVID-DELAY study. The Breast 2022;65:164- 71.

Kim WH, Chang JM, Moon H-G, et al. Comparison of the diagnostic performance of digital breast tomosynthesis and magnetic resonance imaging added to digital mammography in women with known breast cancers. Eur Radiol 2016;26(6):1556-64.

Houssami N, Ciatto S, Macaskill P, et al. Accuracy and surgical impact of magnetic resonance imaging in breast cancer staging: systematic review and meta-analysis in detection of multifocal and multicentric cancer. J Clin Oncol 2008;26(19):3248-58.

Van Loevezijn A, Winter - Warnars GHAO, van der Noordaa MEM, et al. Clinical impact of MRI-detected additional lesions in breast cancer patients treated with neoadjuvant systemic therapy at the Netherlands cancer institute. European J Surg Oncol 2020;46(2):e23-4.

Marinovich ML, Houssami N, Macaskill P, et al. Meta-analysis of magnetic resonance imaging in detecting residual breast cancer after neoadjuvant therapy. J Natl Cancer Inst 2013;105(5):321-33.

Sardanelli F, Boetes C, Borisch B, et al. Magnetic resonance imaging of the breast: Recommendations from the EUSOMA working group. Eur J Cancer 2010;46(8):1296-316.

Groheux D, Giacchetti S, Delord M, et al. 18F-FDG PET/ CT in staging patients with locally advanced or inflammatory breast cancer: Comparison to conventional staging. J Nucl Med 2013;54(1):5-11.

Ng SP, David S, Alamgeer M, et al. Impact of pretreatment combined 18F-fluorodeoxyglucose positron emission tomography/ computed tomography staging on radiation therapy treatment decisions in locally advanced breast cancer. Int J Radiat Oncol Biol Phys 2015;93(1):111-7.

García-Sáenz JÁ, Martín M, Maestro ML, et al. Circulating tumour cells in locally advanced breast cancer. Clin Transl Oncol 2009;11(8):544-7.

Swarnkar PK, Tayeh S, Michell MJ, et al. The Evolving Role of Marked Lymph Node Biopsy (MLNB) and Targeted Axillary Dissection (TAD) after Neoadjuvant Chemotherapy (NACT) for Node-Positive Breast Cancer: Systematic Review and Pooled Analysis. Cancers 2021;13(7):1539.

Kuemmel S, Heil J, Rueland A, et al. A Prospective, Multicenter Registry Study to Evaluate the Clinical Feasibility of Targeted Axillary Dissection (TAD) in Node-positive Breast Cancer Patients. Ann Surg 2022;276(5):E553-62.

Siso C, de Torres J, Esgueva-Colmenarejo A, et al. Intraoperative Ultrasound-Guided Excision of Axillary Clip in Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Therapy (ILINA Trial) : A New Tool to Guide the Excision of the Clipped Node After Neoadjuvant Treatment. Ann Surg Oncol 2018;25(3):784-91.

Caudle AS, Yang WT, Krishnamurthy S, et al. Improved Axillary Evaluation Following Neoadjuvant Therapy for Patients With Node-Positive Breast Cancer Using Selective Evaluation of Clipped Nodes: Implementation of Targeted Axillary Dissection. J Clin Oncol 2016;34(10).

Martínez M, Jiménez S, Guzmán F, et al. Evaluation of Axillary Lymph Node Marking with Magseed® before and after Neoadjuvant Systemic Therapy in Breast Cancer Patients: MAGNET Study. Breast Journal 2022;6111907.

Weinfurtner RJ, Leon A, Calvert A, et al. Ultrasound-guided radar reflector localization of axillary lymph nodes facilitates targeted axillary dissection. Clin Imaging 2022;90:19-25.

Patel R, MacKerricher W, Tsai J, et al. Pretreatment Tattoo Marking of Suspicious Axillary Lymph Nodes: Reliability and Correlation with Sentinel Lymph Node. Ann Surg Oncol 2019;26(8):2452-8.

De Boniface J, Frisell J, Kühn T, et al. False-negative rate in the extended prospective TATTOO trial evaluating targeted axillary dissection by carbon tattooing in clinically node-positive breast cancer patients receiving neoadjuvant systemic therapy. Breast Cancer Research and Treatment 2022;193:589-95.

Lannin DR, Grube B, Shon D, et al. Presentation Breast tattoos for planning surgery following neoadjuvant chemotherapy. Am J Surg 2007;194(4):518-20.

Espinosa-Bravo M, Sao Avilés A, Esgueva A, et al. Breast conservative surgery after neoadjuvant chemotherapy in breast cancer patients: comparison of two tumor localization methods. Eur J Surg Oncol 2011;37(12):1038-43.

Volders JH, Negenborn VL, Spronk PE, et al. Breast-conserving surgery following neoadjuvant therapy-a systematic review on surgical outcomes. Breast Cancer Res Treat 2018;168(1).

Sakamoto N, Fukuma E, Tsunoda Y, et al. Evaluation of the dislocation and long-term sonographic detectability of a hydrogel- based breast biopsy site marker. Breast Cancer 2018;25:575- 82.

Schulz-Wendtland R, Dankerl P, Bani MR, et al. Evaluation of a Marker Clip System in Sonographically Guided Core Needle Biopsy for Breast Cancer Localization Before and After Neoadjuvant Chemotherapy. Geburtshilfe Frauenheilkd 2017;77(2):169-75.

Chagpar AB, Middleton LP, Sahin AA, et al. Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapy. Ann Surg 2006;243(2):257-64.

Jochelson MS, Lampen-Sachar K, Gibbons G, et al. Do MRI and mammography reliably identify candidates for breast conservation after neoadjuvant chemotherapy? Ann Surg Oncol 2015;22(5):1490-5.

Semiglazov V, Eiermann W, Zambetti M, et al. Surgery following neoadjuvant therapy in patients with HER2-positive locally advanced or inflammatory breast cancer participating in the NeOAdjuvant Herceptin (NOAH) study. European J Surg Oncol 2011;37(10):856-63.

Debled M, Macgrogan G, Breton-Callu C, et al. Surgery following neoadjuvant chemotherapy for HER2-positive locally advanced breast cancer. Time to reconsider the standard attitude. Eur J Cancer 2015;51(6):697-704.

Goldberg H, Zandbank J, Kent V, et al. Chemotherapy may eradicate ductal carcinoma in situ (DCIS) but not the associated microcalcifications. Eur J Surg Oncol 2017;43(8):1415-20.

Feliciano Y, Mamtani A, Morrow M, et al. Do Calcifications Seen on Mammography After Neoadjuvant Chemotherapy for Breast Cancer Always Need to Be Excised? Ann Surg Oncol 2017;24(6):1492-8.

Kim Y-S, Chang JM, Moon H-G, et al. Residual Mammographic Microcalcifications and Enhancing Lesions on MRI After Neoadjuvant Systemic Chemotherapy for Locally Advanced Breast Cancer: Correlation with Histopathologic Residual Tumor Size. Ann Surg Oncol 2016;23(4):1135-42.

Santoro S, Loreti A, Cavaliere F, et al. Neoadjuvant chemotherapy is not a contraindication for nipple sparing mastectomy. Breast 2015;24(5):661-6.

Agresti R, Sandri M, Gennaro M, et al. Evaluation of Local Oncologic Safety in Nipple-Areola Complex-sparing Mastectomy After Primary Chemotherapy: A Propensity Score-matched Study. Clin Breast Cancer 2017;17(3):219-31.

Baselga J, Bradbury I, Eidtmann H, et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet 2012;379(9816):633-40.

Gianni L, Pienkowski T, Im Y-H, et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol 2012;13(1):25-32.

Schneeweiss A, Chia S, Hickish T, et al. Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline- containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA). Ann Oncol 2013;24(9):2278-84.

Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials. Lancet Oncol 2018;19(1):27-39.

Gnant M, Harbeck N, Thomssen C. St. Gallen/Vienna 2017: A Brief Summary of the Consensus Discussion about Escalation and De-Escalation of Primary Breast Cancer Treatment. Breast Care (Basel) 2017;12(2):102-7.

Wagner J, Boughey JC, Garrett B, et al. Margin assessment after neoadjuvant chemotherapy in invasive lobular cancer. Am J Surg 2009;198(3):387-91.

Volders JH, Haloua MH, Krekel NMA, et al. Neoadjuvant chemotherapy in breast-conserving surgery-Consequences on margin status and excision volumes: A nationwide pathology study. Eur J Surg Oncol 2016;42(7):986-93.

Pata G, Bartoli M, Bianchi A, et al. Additional Cavity Shaving at the Time of Breast-Conserving Surgery Enhances Accuracy of Margin Status Examination. Ann Surg Oncol 2016;23(9):2802-8.

Wang K, Ren Y, He J. Cavity shaving plus lumpectomy versus lumpectomy alone for patients with breast cancer undergoing breast-conserving surgery: A systematic review and meta-analysis. PLoS One 2017;12(1):1-14.

Chagpar AB, Killelea BK, Tsangaris TN, et al. A Randomized, Controlled Trial of Cavity Shave Margins in Breast Cancer. N Engl J Med 2015;373(6):503-10.

Rea D, Tomlins A, Francis A. Time to stop operating on breast cancer patients with pathological complete response? Eur J Surg Oncol 2013;39(9):924-30.

Van la Parra RFD, Kuerer HM. Selective elimination of breast cancer surgery in exceptional responders: historical perspective and current trials. Breast Cancer Res 2016;18(1):28.

Di Cosimo S, Campbell C, Azim HA, et al. The use of breast imaging for predicting response to neoadjuvant lapatinib, trastuzumab and their combination in HER2-positive breast cancer: Results from Neo-ALTTO. Eur J Cancer 2018;89:42-8.

Boughey JC, Suman VJ, Mittendorf EA, et al. Factors affecting sentinel lymph node identification rate after neoadjuvant chemotherapy for breast cancer patients enrolled in ACOSOG Z1071 (Alliance). Ann Surg 2015;261(3):547-52.

Sosa A, Lei X, Woodward WA, et al. Trends in Sentinel Lymph Node Biopsies in Patients with Inflammatory Breast Cancer in the US. JAMA New Open 2022;5(2).

Hunt KK, Yi M, Mittendorf EA, et al. Sentinel lymph node surgery after neoadjuvant chemotherapy is accurate and reduces the need for axillary dissection in breast cancer patients. Ann Surg 2009;250(4):558-66.

Kuehn T, Bauerfeind I, Fehm T, et al. Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): A prospective, multicentre cohort study. Lancet Oncol 2013;14(7):609-18.

Boileau J-F, Poirier B, Basik M, et al. Sentinel node biopsy after neoadjuvant chemotherapy in biopsy-proven node-positive breast cancer: the SN FNAC study. J Clin Oncol 2015;33(3):258- 64.

Boughey JC, Suman VJ, Mittendorf EA, et al. Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients with Node-Positive Breast Cancer. JAMA 2013;310(14):1455.

Barrio AV, Mamtani A, Edelweiss M, et al. How Often Is Treatment Effect Identified in Axillary Nodes with a Pathologic Complete Response After Neoadjuvant Chemotherapy? Ann Surg Oncol 2016;23(11):3475-80.

Cordoba O, Carrillo-Guivernau L, Reyero-Fernández C. Surgical Management of Breast Cancer Treated with Neoadjuvant Therapy. Breast Care 2018;13(4):238-43.

Aukema TS, Russell NS, Wesseling J, et al. Extensive soft tissue resection with autologous tissue closure for locally recurrent breast cancer: Lasting local control and acceptable morbidity. Eur J Surg Oncol 2009;35(5):469-74.

Gonfiotti A, Salvicchi A, Voltolini L. Chest-Wall Tumors and Surgical Techniques: State-of-the-Art and Our Institutional Experience. J Clin Med 2022;11(19).

Tsai CH, Tzeng HE, Juang WK, et al. Curative use of forequarter amputation for recurrent breast cancer over an axillary area: A case report and literature review. World J Surg Oncol 2014;12(1):1-6.

Da Costa Vieira RA, Andrade WP, Vieira SC, et al. Surgical management of locally advanced breast cancer: Recommendations of the Brazilian Society of Surgical Oncology. J Surg Oncol 2022;126(1):57-67.

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